By inhibiting the brains release of dopamine and other neurochemicals, cocaine can cause serious and often irreversible damage to neurons within the brain. In autopsies, cocaine users had a reduced number of dopamine neurons. When flooded with the excess of dopamine created during a cocaine high, the brain reacts by making less dopamine, getting rid of this excess, and shutting down the dopamine neurotransmitters, sometimes permanently.
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Never did it but i heard when u come off it feels like hell