which of the following events is unlikely to be associated with cancer?
a. mutations of a cellular proto-oncogene in a normal diploid cell
b. chromosomal translocations with breakpoints near a cellular proto-oncogene
c. deletion of a cellular proto-oncogene
d. mitotic nondisjunction in a cell carrying a deletion of a tumor-suppressor gene
e. incorporation of a cellular oncogene into a retrovirus chromosome
a. mutations of a cellular proto-oncogene in a normal diploid cell
b. chromosomal translocations with breakpoints near a cellular proto-oncogene
c. deletion of a cellular proto-oncogene
d. mitotic nondisjunction in a cell carrying a deletion of a tumor-suppressor gene
e. incorporation of a cellular oncogene into a retrovirus chromosome
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C.
Proto-oncogenes turn into oncogenes of which you only need one copy (dominant), so (A) will produce cancer. B will produce cancer if it affects a coding region that down regulates the gene. C won't produce cancer, and the good copy is still good (again you only need one bad copy, so this doesn't increase your likelyhood). D will contribute in the cell lacking the gene. E could be true as well. I'd go with C.
By E true as well, I meant that it could go ahead and give that to other cells.
Proto-oncogenes turn into oncogenes of which you only need one copy (dominant), so (A) will produce cancer. B will produce cancer if it affects a coding region that down regulates the gene. C won't produce cancer, and the good copy is still good (again you only need one bad copy, so this doesn't increase your likelyhood). D will contribute in the cell lacking the gene. E could be true as well. I'd go with C.
By E true as well, I meant that it could go ahead and give that to other cells.